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Specifications Synonym: Acetyl CoA, Acetyl-S- CoACAS Number: 102029-73-2Empirical Formula (Hill Notation): C23H38N7O17P3SMolecular Weight: 809.57MDL Number: MFCD00078858PubChem Substance ID: 24890621Application An essential cofactor in enzymatic acetyl transfer reactions.Acetyl-CoA is an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. It is formed either by the oxidative decarboxylation of pyruvate in mitochondria, by the oxidation of long-chain fatty acids, or by the oxidative degradation of certain amino acids. Acetyl-CoA is the starting compound for the citric acid cycle (Kreb's cycle). It is also a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. Acetyl-CoA positively regulates the activity pyruvate carboxylase. It is a precursor of the neurotransmitter acetylcholine. Histone acetylases (HAT) use Acetyl-CoA as the donor for the acetyl group use in the post-translational acetylation reactions of histone and non-histone proteins.Preparation Note Prepared enzymaticallyBiochem/physiol Actions Acetyl-CoA is an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. It is formed either by the oxidative decarboxylation of pyruvate in mitochondria, by the oxidation of long-chain fatty acids, or by the oxidative degradation of certain amino acids. Acetyl-CoA is the starting compound for the citric acid cycle (Kreb's cycle). It is also a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. Acetyl-CoA positively regulates the activity pyruvate carboxylase. It is a precursor of the neurotransmitter acetylcholine. Histone acetylases (HAT) use Acetyl-CoA as the donor for the acetyl group use in the post-translational acetylation reactions of histone and non-histone proteins.Quality Level: PREMIUMAssay: 5 =93% (HPLC)Form: powderSolubility: H2O: soluble100 mg/mLStorage Temp.: H -20°C LGene Information: human ... CHAT, HAT1, KAT2A, KAT2B, KAT5. mouse ... HAT1, KAT2A, KAT2B; KAT5. rat ... HAT1, KAT2A, KAT2B, KAT5.
