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Casein Kinase I? (CKIε) is a product of a family of proteins involved in the regulation of various cytoplasmic and nuclear processes including DNA replication and repair. CKIε is a 47.3kDa serine/threonine kinase that plays a role similar to previously described CKI isoforms. It phosphorylates known CKI substrates, including a CKI-specific peptide. In addition, it is inhibited by CKI-7, an inhibitor of other CKI isoforms. CKIε contains a core kinase domain of 285 amino acids which is 53-98% identical to other isoforms and is most similiar in structure to CKIδ. Since various human and yeast CKI proteins exhibit both sequence and functional similarities, CKIε may be involved in mammalian DNA metabolism.Immunofluorescence, Immunoprecipitation, Western Blotting
