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Clone 1C6/CXCR3 reacts with the human form of the 40 - 41kDa seven-transmembrane protein and member of the G protein-coupled receptor family. CXCR3 is expressed primarily on activated T cells that infiltrate inflammatory sites. It has also been detected on some circulating T cells, B cells, and NK cells. Reports show that some CXCR3 T cells also express CCR5 and are mostly CD45RO cells. Three ligands for CXCR3 have been identified. They are interferon-γ inducible 10kDa protein (IP-10), monokine induced by interferon-γ (MIg), and interferon-inducible T-cell γ chemoattractant (I-TAC). These chemokines are produced by a variety of cells upon stimulation by IFN γ and interact with CXCR3 to mediate T-cell chemotaxis. This reagent has been reported to be suitable for immunohistochemical staining of acetone-fixed, frozen sections and/or formalin-fixed, paraffin-embedded tissue sections with citrate pretreatment. Clone CXCR3 also cross reacts with a subset of peripheral blood lymphocytes of baboon, and both rhesus and cynomolgus macaque monkeys. The distribution of lymphocytes is similar to that observed with peripheral blood lymphocytes from normal human donors. CXCR3 has been clustered as CD183 in the VIIth HLDA workshop. This product is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.Host Species: MouseClone: 1C6/CXCR3Isotype: IgG1, κCross Reactivity: HumanFlow Cytometry
