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The monoclonal antibody 2B11/CXCR4 reacts with the mouse CD184, which is also known as CXC chemokine receptor, CXCR4. CXCR4 (previously known as fusin, LESTR and HUMSTR), a seven-transmembrane, G-protein-coupled receptor, is the specific receptor for CXC chemokines, SDF-1/CXCL12. Mouse CXCR4 showed 91% homology at amino acid level with human CXCR4. The CXCR4 is widely expressed by hematopoietic and non hematopoietic cell types including PMN, monocytes, T cells, B cells, CD34 progenitor cells, endothelial cells, neurons and astrocytes. The human CXCR4 is used by T-tropic HIV-1 as a co-receptor for viral entry. The mouse CXCR4 gene has been mapped to chromosome 1. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.Host Species: RatClone: 2B11/CXCR4Isotype: IgG2b κSpecies Reactivity: MouseImmunogen: GST-NCXCR4 fusion proteinFlow Cytometry
