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Reacts with a single-chain 105-120kDa heavily O-glycosylated transmembrane glycoprotein expressed on a hemotopoietic progenitor cells, vascular endothelium and some tissue fibroblasts. The intracellular chain of the CD34 antigen is a target for phosphorylation by activated protein kinase C suggesting CD34 may play a role in signal transduction. CD34 may also play a role in adhesion of specific antigens to endothelium. Clone 581 reacts with the class III CD34 epitope, it is resistant to neuraminidase, chymopapain and glycoprotease. 581 blocks reactivity of another anti-CD34 monoclonal antibody, 8G12. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.
