CD49e Mouse anti-Human, Unlabeled, Clone: 1, BD, Mouse Monoclonal Antibody, Each

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Integrins are membrane receptors that mediate cell-cell or cell-matrix adhesion. They are transmembrane heterodimers composed of α and β subunits and are connected to the cytoskeleton. At least 20 integrins, formed from combinations of 12 α and 9 β subunits, have been reported. Many of these have been implicated as transducers of molecular signals. The integrin α5 subunit is 1049 amino acids with a molecular weight of 150-165kDa. α5 and β1 form a functional fibronectin receptor which is important for vascular development in mice. Both subunits of the fibronectin receptor are heavily glycosylated in their extracellular domains. This modification is essential for proper cell attachment to basal membranes. Integrin α5 has been reported to suppress apoptosis by a Bcl-2 pathway and the C-terminal region is critical for cell motility and cytoskeletal rearrangements.