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Details
Clone RPA-T8 reacts with the α subunit (32kDa) of the two-chain complex expressed on T-cytoxic/suppressor cell populations. CD8 molecule binds to HLA class I molecules during interaction of CD8 T cells with antigen-presenting cells or with target cells. RPA-T8 reacts with approximately 13-48% of peripheral blood lymphocytes and 80% of thymocytes, as well as a subset of NK cells. RPA-T8 and HIT8a (Mfr. No.555337) are not cross-blocking. This clone also reacts with a subset of peripheral blood lymphocytes, but not monocytes nor granuloyctes, of baboon and both rhesus and cynomolgus macaque monkey. In general, a higher frequency of CD8 and CD4 CD8 lymphocytes are observed in non-human primates compared to normal human donors. This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.
