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The immunogen used to raise R139 antibody was C1q-binding protein preparation derived from U937 cell lysates, as described. Human CDw93 (C1qRp) is a 631 AA, single chain type I membrane glycoprotein expressed on cells of myeloid origin, endothelial cells, and hematopoietic progenitor cells. Human, murine and rat protein sequences have been deduced from cDNA clones and are known to be similar in sequence and organization. CDw93 (C1qRp) binds C1q, the recognition subunit of the first component (C1) of the complement pathway, as well as MBL (Mannose-binding-lectin) and SPA (Pulmonary Surfactant Protein A). Multivalent interaction of CDw93 (C1qRp) expressing cells with C1q, MBL, and SPA, induces enhancement of phagocytosis of suboptimally opsonized particles and/or cellular debris. Antibody R139 neutralizes/blocks C1q-mediated enhancement of phagocytosis, as reported. In addition clone R139 is suitable to detect CDw93 (C1qRp) expression on cells by flow cytometry, CDw93 (C1qRp) in cellular lysates by Western blotting or immunoprecipitation. CDw93 (C1qRp) has been reported to define a human stem cell population with hematopoietic and hepatic potential.
