Diphenylmethane derivative and Na /K ATPase inhibitor that stimulates colonic muscle contractions. It indirectly activates PKC, downregulates the expression of aquaporin 3 channels, stimulates enteric nerves, and increases NaCl secretion, Each

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Bisacodyl is a diphenylmethane derivative that exhibits gastrointestinal motility modulating (laxative) activity. Bisacodyl activates macrophages, activating PKC, increasing PGE2 secretion, and downregulating expression of aquaporin 3 channels; it may also inhibit the Na /K ATPase. As a result of these actions, colonic fluid and NaCl secretion is increased. Bisacodyl also stimulates enteric nerves, increasing contractions.