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Members of the Ras superfamily of GTPases are distantly related to the heterotrimeric G proteins and shuttle between inactive and active GTP-bound forms. Conversion between these forms is controlled by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Rho is a GTPase that regulates cell morphology and motility in response to extracellular signals. p190A, p190B, and p122 RhoGAPs all contain RhoGAP domains and regulate the GTPase activity of Rho. p122 RhoGAP exhibits GAP activity for RhoA, but not Rac1, and binds and activates PLC-δ1. Microinjection of p122 RhoGAP suppresses LPA-induced formation of stress fibers and focal adhesions. Deleted in liver cancer-1 (DLC-1) was identified by its frequent deletion in liver cancer and is a human homologue of rat p122 RhoGAP. DLC-1 is expressed in many hepatocellular carcinoma tissues and cell lines and could be an important tumor suppressor gene. In normal human tissues, DLC-1 is expressed widely with the highest expression in heart and lung. Both p122 RhoGAP and DLC-1 have RhoGAP domains toward their C-terminal regions, which is thought to be important for regulation of Rho GTPase activity in many tissues.Host Species: MouseClone: 3Isotype: IgG1Species Reactivity [for Features Main]: HumanImmunogen: Human DLC-1 aa. 47-249Immunofluorescence, Western Blotting
