Simplicon Reprogramming RNA (OKSG), For use as transfection reagent, Each

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Safe, efficientStem cell type: Induced pluripotent stem cellsGenerates integration free, virus-free human iPS cellSingle transfection step of self-replicating synthetic RNA for Oct4, Klf4, Sox2, Glis1Integration free, footprint free iPS cellsNo risk of genomic integrationSafe, virus free, synthetic polycistronic RNA replicon (all four reprogramming factors in 1 RNA str)Only 1 day transfection requiredRNA replicon is able to self-replicate, elliminating need for laborious daily transfection of multiple individual mRNAs over 14 day periodEfficient rapid reprogramming No screening required to ensure viral remnants are not presentControlled elimination of synthetic RNA replicon by removal of B18R protein Validated for reprogramming in feeder-based feeder-free culture conditio