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Foxp3 is a 50-55kDa protein also known as Forkhead box P3, JM2, or IPEX. It is a member of the forkhead or winged helix family of transcription factors and is specifically expressed by T regulatory (Treg) cells. Foxp3 has been reported to be a key regulatory protein for Treg cell development and function. Ectopic expression of Foxp3 in conventional T cells is sufficient to induce suppressive activity, repress the production of cytokines such as IL2 and IFN-γ, and upregulate Treg cell-associated molecules such as CD25, CTLA4 and GITR. It has been found that the mutation of Foxp3 is responsible for “scurfy” mice. When overexpressed, Foxp3 leads to poor T cell proliferation and activation. Monoclonal antibody MF23 reacts with mouse Foxp3. Immunoblotting with MF23 antibody has confirmed it recognizes an epitope between 1-87 amino acids in the N-terminal domain.Host Species: RatClone: MF23Isotype: IgG2bSpecies Reactivity: MouseImmunogen: Mouse Foxp3 Recombinant ProteinIntracellular Staining
