H-His-Cys-Lys-Phe-Trp-Trp-Oh 5, Each

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H-His-Cys-Lys-Phe-Trp-Trp-Oh^ 5Mg Potent Inhibitor Of The Hiv-Encoded Integrase (In), The Enzyme Responsible For The Integration Of Hiv Dna Into The Human Genome. Hckfww Inhibits In-Mediated 3'Processing And Integration With An Ic50 Of 2 ªm. The Peptide Is Also Active On In Proteins From Other Retroviruses Such As Hiv-2, Feline Immunodeficiency Virus And Moloney Murine Leukemia Virus. It Was Also Found To Inhibit The Disintegration Reaction, Sug Gesting That This Hexapeptide Acts At Or Near The Catalytic Site Of In. Cas: 172546-75-7 C46H55N11O7S Fw: 906.08