It is used to treat bone diseases such as osteoporosis. It inhibits bone resorption and osteoclast formation but does not have any effects on bone mineralization. It also increases d? T cell activation and inhibits tumor growth, Each

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Alendronate is a second generation bisphosphonate that exhibits anti-resorptive, anti-inflammatory, immunomodulatory, and anticancer chemotherapeutic activities. Alendronate inhibits bone resorption but does not have any effects on bone mineralization; it also inhibits osteoclast formation and decreases phosphorylation of Akt and ERK1/2 in vitro. In animal models, alendronate decreases production of Th2 and Th17 cytokines and eotaxin-2, suppressing antigen-induced pulmonary immune responses. Additionally, this compound increases δγ T cell activation and inhibits tumor growth in vivo.Grade: ≥98%