KEAP1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Rabbit Polyclonal Antibody, Each

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A suggested positive control is human lung tissue lysate. PA5-34454 can be used with blocking peptide PEP-1496. The PA5-34454 immunogen is located within the last 50 amino acids of KEAP1. Predicted molecular ∽ 70kD. In Western blot applications, this antibody has been observed to detect a band at: 65-70kD. Predicted species reactivity based on immunogen sequence: Pig: (100%).KEAP1 (kelch-like ECH-associated protein 1) is a stress sensing adaptor for the Cullin3 (Cul3)-dependent E3 ubiquitin ligase complex that negatively regulates NRF2 (NF-E2-related factor 2) and plays a role in the oxidative stress response. It targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome. KEAP1 contains an amino terminal BTB/POZ domain and a carboxyl terminal KELCH domain which are required for interaction with NRF2, and in binding Cul3-E3 ubiquitin ligase. Altered expression of NRF2 is associated with chronic obstructive pulmonary disease (COPD). KEAP1 also targets the down regulation of NF-Kappa-B activity by targeting IKKBeta degradation. Mutation of the KEAP1 gene is found in lung cancer.