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Specifications Synonym: 1,3,7-Trimethylxanthine, CaffeineCAS Number: 58-08-2Empirical Formula (Hill Notation): C8H10N4O2Molecular Weight: 194.19Beilstein Registry Number: 17705EC Number: 200-362-1MDL Number: MFCD00005758PubChem Substance ID: 24886771Biochem/physiol Actions A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.Grade: analytical standard; for the calibration of the thermosystem 900Quality: traceable to primary standards (LGC)Shelf Life: ± limited shelf life, expiry date on the certificate and labelMP: 234-236.5 °C(lit.)Gene Information: human ... ADORA1(134), ADORA2B(136), ADORA3(140), PDE4B(5142), mouse ... Adora2b(11541), rat ... Adora1(29290), Adora2a(25369)
