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MPEP hydrochloride, Potent mGlu5 antagonist; also positive allosteric modulator of mGlu4 receptors, Each

418.76

Details

MPEP hydrochloride is a potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.

Additional Information

SKU 10176342
UOM Each
UNSPSC 41116105
Manufacturer Part Number 1212/10