TCR β chain Hamster anti-Mouse, NA/LE, Unlabeled, Clone: H57-597, BD, Hamster Monoclonal Antibody, Each

Details

The H57-597 antibody reacts with a common epitope of the β chain of the T-cell Receptor (TCR) complex on αβ TCR-expressing thymocytes and peripheral T lymphocytes and NK1.1 thymocytes and NK-T cells of all mouse strains tested. It dodoes not react with γδ TCR-bearing T cells. In the fetal and adult thymus, the TCR β-chain may form homodimers or pair with the pre-TCR α-chain on the surface of immature thymocytes before expression of the TCR α-chain. Plate-bound or soluble H57-597 antibody activates αβ TCR-bearing T cells, and plate-bound mAb can induce apoptotic death.