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21WAF1/Cip1/Sdi1/Pic1 is a tumor suppressor protein. Expression of p21WAF1 is induced by wild type, but not mutant, p53 suppressor protein. The p21WAF1 protein binds to cyclin/CDK complexes and inhibits their kinase activity thereby stopping cell cycle progression. It also binds to PCNA (proliferating cell nuclear antigen) and blocks DNA replication but not the DNA repair process. Host Species: MouseClone: HJ21; same as WA-1Isotype: IgG1Species Reactivity: Human and Rat. Others not known.Epitope: Not determinedImmunogen: Human recombinant p21 proteinMolecular Weight: 21kDaPositive Control: PC12, Ls174T or Raji cellsCellular Localization: Nuclear Recommended for:Immunohistochemistry (Not suitable)Western BlottingImmunofluorescenceImmunoprecipitation (Not suitable)Flow Cytometry (Not Suitable) Note:USA: RUO; Int'l: RUO
