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57Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms. Host Species: MouseClone: 57P06; same as KP10Isotype: IgG2b/κSpecies Reactivity: Human and Mouse. Others not known.Epitope: Not determinedImmunogen: Recombinant human p57Kip2 proteinMolecular Weight: 57kDaPositive Control: LS174T cells, Colon CA or placentaCellular Localization: Nuclear Recommended for:Immunohistochemistry (Formalin/paraffin)Western Blotting (Not suitable)Immunoprecipitation (Native verified)
