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PAX-5 is a B-cell-specific activator protein (BSAP). In the early stages of B cell developmemt, PAX-5 influences the expression of several B-cell-specific genes, such as CD19 and CD20. PAX-5 is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells. PAX-5 is expressed in most B-cell malignancies (pre-B and mature B cell lymphomas/leukemias). Over 90% of cases are positive for PAX-5 in Hodgkin's lymphoma, lymphoplasmacytic lymphoma, Merkel cell and small cell carcinoma. T-cell lymphomas, myeloma/plasmacytoma and carcinoid tumors are negative for PAX-5. Host Species: RabbitClone: SP34Isotype: IgGSpecies Reactivity: Human. Others not tested.Immunogen: Synthetic peptide derived from the C-terminus of human PAX-5 proteinMolecular Weight: 50kDaPositive Control: TonsilCellular Localization: Nuclear Recommended for:Immunohistochemistry (Formalin/paraffin)
