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TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A). It also has affinity for the active form of 92kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-2 inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. Host Species: MouseClone: 3A4Isotype: IgG2a/κSpecies Reactivity: Human, Mouse, Rat, Rabbit, Cow and Guinea Ppig. Others not known.Epitope: N-terminalImmunogen: A synthetic peptide from the N-terminal region of human TIMP-2 proteinMolecular Weight: 21kDaPositive Control: Conditioned, serum-free medium from (TPA-treated) HFL-1 cells; Pancreatic or colon CACellular Localization: Cytoplasmic Recommended for:Immunohistochemistry (Formalin/paraffin only)Western BlottingImmunoprecipitation (Not suitable) Note:USA: RUO; Int'l: RUO
