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Transglutaminase II catalyzes calcium-dependent post-translational modification of proteins by formation of an isopeptide bond within or between polypeptide chains. It is also known as TGC, tTG, type II-, Gh, cytosolic-, liver-, endothelial-, erythrocyte-, cellular-transglutaminase. Different tissues and cell types express varying amounts of tissue transglutaminase with a markedly hugh expression in rheumatoid lesions. It is implicated in programmed cell death, signal transduction, drug-resistance, cell growth, endocytosis, insulin secretion, cell adhesion, cataract formation, and wound healing. Host Species: MouseClone: CUB 7402Isotype: IgG1/κSpecies Reactivity: Human, Dog, Rabbit and Guinea Pig. Does not react with mouse and rat. Others not known.Epitope: aa 447-478Immunogen: Purified guinea pig liver TGase IIMolecular Weight: 77-85kDaPositive Control: HUVEC cells, Breast CACellular Localization: Cytoplasm, membrane and extracellular matrix Ab-1 inhibits the TGase II activity. Recommended for:Immunohistochemistry (Formalin/paraffin)Western BlottingImmunofluorescenceImmunoprecipitation (Native and denatured)Affinity PurificationBiological Blockade Note:USA: RUO; Int'l: RUO
