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Microtubules, the major cytoskeletal elements found in all eukaryotic cells, consist of Tubulin, which is a dimer of two 55kDa subunits: α and Β. Microtubules play key roles in chromosome segregation in mitosis, intracellular transport, ciliary and flagellar bending, and structural support of the cytoskeleton. Host Species: MouseClone: DM1AIsotype: IgG1/κSpecies Reactivity: Human, Cow, Pig, Rat, Mouse, Guinea Pig, Gerbil, Frog and Chicken. Others not known.Epitope: aa 426-450Immunogen: Native chick brain microtubulesMolecular Weight: 57kDaPositive Control: Ls174T, MAD109 cells; skin or lungCellular Localization: Cytoplasmic Ab-2 causes the 10nm filaments to collapse into large lateral aggregates collecting in the cell periphery or tight juxtanuclear caps. It does not block microtubule assembly. It does not inhibit polymerization or depolymerization of platelet tubulin in vitro. It blocks (by 70-80%) the ability of tubulin dimers (with GppNHp bound) to promote a stable inhibition of adenylyl cyclase. Recommended for:Immunohistochemistry (Formalin/paraffin)Western BlottingImmunofluorescenceImmunoprecipitation (Native and denatured)Electron Microscopy Note:USA: RUO; Int'l: RUO
