ASP 2535, Potent and selective GlyT1 inhibitor, Each

Details

ASP 2535 is a potent and selective GlyT1 inhibitor (IC50 = 92 nM). Exhibits 50-fold selectivity over GlyT2. Attenuates MK 801 -induced working memory deficits and PCP -induced visual learning deficits in mice. Orally available and brain penetrant.