Bay 55-9837, Potent And Selective Vpac2 Agonist, Each

Details

Bay 55-9837 is a selective vpac2 receptor agonist (ec50 values are 0.4, 100 And >1000 nm for vpac2, vpac1 and pac1, respectively in a camp accumulation assay; ic50 values are 60, 8700 and >10000 nm for vpac2, vpac1 and pac1, respectively in a competition binding assay). Stimulates glucose-dependent insulin secretion in isolated human pancreatic islets. Reduces hiv-1 viral replication and shows cooperative effects when given in conjunction with vpac1 agonists.