Cariporide, Selective NHE1 inhibitor; cardioprotective and antitumor, Each
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Details
Cariporide is a selective Na /H exchanger isoform 1 (NHE1) inhibitor (IC50 values are 0.05, 3 and 1000 μM for NHE1, NHE3 and NHE2 respectively). Attenuates ischemia-induced cardiomyocyte apoptosis in vitro. Reduces cardiac arrhythmia in vivo. Also promotes apoptosis in cancer cells overexpressing NHE1. Orally active.
Additional Information
SKU | 10341347 |
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UOM | Each |
UNSPSC | 41116105 |
Manufacturer Part Number | 5358/50 |