Pregnenolone sulfate sodium salt, NMDA potentiator; also GABAA inhibitor and TRPM3 activator, Each

Details

Pregnenolone sulfate sodium salt is a highly potent neurosteroid with multiple actions. Enhances intracellular Ca2 upon NMDA receptor-mediated synaptic activity (EC50 ∽ 2 pM) and potentiates NMDA responses. Inhibitor at GABAA receptors (IC50 values are 0.4 to >300 μM, depending on specific subunit conformation). Activates CREB phosphorylation, augments LTP and cognitive behavior in rat memory models. Also activates TRPM3 channels.