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XL 184, Potent VEGFR inhibitor; also inhibits other RTKs, Each

2,481.70

Details

XL 184 is a potent VEGFR inhibitor (IC50 = 0.035 nM); also inhibits c-Met, KIT, RET, FLT4, AXL, FLT3, FLT1 and Tie2 (IC50 values are 1.3, 4.6, 5.2, 6, 7, 11.3, 12 and 14.3 nM, respectively). Induces intratumoral hypoxia and apoptosis. Reduces tumor invasion and metastasis in vivo. Antiangiogenic.

Additional Information

SKU 10268493
UOM Each
UNSPSC 41116105
Manufacturer Part Number 5422/50