TYR-(D-DAB4,ARG5,D-TRP8)-CYCLO ,Each

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TYR-(D-DAB4,ARG5,D-TRP8)-CYCLO-SOMA, 1mg High affinity ligand for all five somatostain receptors (sst1-sst5). In AtT-20 mouse anterior pituitary tumor cells which mainly express sst2 and sst5 receptors the binding affinity of this somatostatin analog was found to be higher than that of somatostatin-14 (H-1490) and octreotide (H-5972). In a model of epileptogenesis, however, KE 108 did not exhibit antiepileptic activity sug gesting that the high potency and efficacy of a synthetic ligand to all known somatostatin receptors may not reproduce entirely the effects of the natural ligand. CAS: 496849-46-8 C67H85N15O11 FW: 1276.51. Synonym: KE 108